NCL New Concept Lab GmbH, a privately-owned company located at Möhlin Switzerland, is dedicated to developing novel laboratory devices aimed at simplifying lab work and improving laboratory performance. It holds ownership of several proprietary and patented technologies. The company's groundbreaking solutions will empower scientists and researchers across pharmaceutical and biotech industries, healthcare facilities, as well as universities and academic institutes, facilitating their crucial work and driving progress in scientific discovery and innovation. With expertise and proficiency spanning various biotech disciplines, notably in assay development, cell biology, and molecular biology, the company ingeniously crafted several user-friendly labwares, including IMAPlate™ 5RC96, Assembling Organ on a Chip (AOOC), and device for seeding and cultivating cells on BLI sensor, thereby equipping scientists and researchers to efficiently pursue their studies.
IMAPlate™ 5RC96 (Patented)
The IMAPlate™ 5RC96 is an exceptionally versatile tool with a myriad of functions for laboratory applications. Acting as a 5 μl self-dosed 96-channel manual pipette, it empowers scientists and researchers to simultaneously transfer 96 samples for various tasks such as sample addition, replicates preparation, inoculation, or spotting.
It can also operate as a full spectrum micro-cuvette plate, streamlining the UV quantification of DNA, RNA, and protein with minimal volume in a plate reader. Furthermore, it boosts the sensitivity of miniature assays, such as add-and-mix homogeneous assays and solid-phase heterogeneous assays, accommodating volumes ranging from 5 to 25 μl. For instance, harnessing the IMAPlate™ 5RC96 for results readout can substantially amplify the sensitivity of conventional ELISAs by approximately 10-fold, achieved through a reduction in colorization reaction volume within the 96-well plate.
Expanding beyond its conventional applications, the IMAPlate™ 5RC96 provides invaluable in cell biology, streamlining the preparation of single spheroids, multi-spheroids, and the selection of clones. This versatility renders it indispensable for a broad spectrum of laboratory tasks and research endeavors.
Last but not least, its standard 96-well format enables seamless integration with automated liquid handlers, further enhancing efficiency and reproducibility in experimental workflows.
Assembling Organ on a Chip (Patent Pending)
The Assembling Organ on a Chip technology (AOoC) simplifies cell cultivation by bypassing the complexities of on-site cultivation. Cultivating cells becomes as straightforward as that doing in a 96-well plate. AOoC provides flexibility in experimental setup, allowing adjustments in cell amount, type, and 2D or 3D culture forms even during experiments. This flexibility enables researchers to pre-select well-growing and well-characterized cells, ensuring the success of their experiments. Models can be freely constructed by combining various cells before and during experiments. Retrieving cells from the platform is seamless and disruption-free. Multi-parameter analysis is achievable through off-site assays, enhancing the depth of experimental insights.
Device for seeding and cultivating cells on BLI sensor (Patent Pending)
Biolayer interferometry (BLI) is a label-free optical technique that measures changes in interference patterns as biomolecules bind to a sensor surface. In a cell-based BLI assay, cells are typically cultured on the sensor surface, allowing researchers to monitor interactions between cell surface receptors, membrane proteins, or intracellular molecules and their ligands or substrates in real-time. This method offers advantages such as high sensitivity, minimal sample preparation, and the ability to study interactions in physiological conditions.
In response to the considerable challenge of culturing cells on tiny sensor surfaces, the company has engineered a device to streamline cell seeding and cultivation, akin to the methodology employed in a 96-well plate. This advancement aims to empower scientists and researchers, enabling them to harness cell-based BLI technology to expedite breakthroughs in drug development, protein-protein interaction studies, and the exploration of cellular signaling pathways.